|Other Accession||Q6PFX9, NP_003738.2|
|Other Names||Tankyrase-1, TANK1, ADP-ribosyltransferase diphtheria toxin-like 5, ARTD5, Poly [ADP-ribose] polymerase 5A, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyrase I, TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 71-89 of HUMAN TNKS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP- ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nuclear pore complex Chromosome, telomere. Cytoplasm, cytoskeleton, spindle pole Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4- vesicles (PubMed:22864114). A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501). During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206). Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061)|
|Tissue Location||Ubiquitous; highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Davila, S., et al. Genes Immun. (2010) In press :
Shen, J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):219-228(2010)
Appierto, V., et al. Mol. Cancer Ther. 8(12):3360-3368(2009)
Varadi, V., et al. Eur. J. Cancer 45(17):3008-3016(2009)
Choi, J.E., et al. Cancer Epidemiol. Biomarkers Prev. 18(10):2773-2781(2009)
Lyons, R.J., et al. J. Biol. Chem. 276(20):17172-17180(2001)
Chi, N.W., et al. J. Biol. Chem. 275(49):38437-38444(2000)
Smith, S., et al. J. Cell. Sci. 112 (PT 21), 3649-3656 (1999) :
Zhu, L., et al. Genomics 57(2):320-321(1999)
Smith, S., et al. Science 282(5393):1484-1487(1998)
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