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CDC42BPA Blocking Peptide (C-term P1669)

Synthetic peptide

Product Information
Primary Accession Q5VT25
Additional Information
Gene ID 8476
Other Names Serine/threonine-protein kinase MRCK alpha, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH713361}, KIAA0451
Target/Specificity The synthetic peptide sequence is selected from aa 1669-1683 of HUMAN CDC42BPA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC42BPA {ECO:0000312|EMBL:CAH71336.1}
Synonyms KIAA0451
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O54874}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96} Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell- cell junction. This concentration is PH-domain dependent Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96}
Tissue Location Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
Research Areas
Citations (0)

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CDC42BPA is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization.


Dong, J.M., et al., Eur. J. Cell Biol. 81(4):231-242 (2002).
Tan, I., et al., Mol. Cell. Biol. 21(8):2767-2778 (2001).
Lam, L.T., et al., Hum. Mol. Genet. 9(14):2167-2173 (2000).
Nakamura, N., et al., Genes Cells 5(7):571-581 (2000).
Leung, T., et al., Mol. Cell. Biol. 18(1):130-140 (1998).

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$ 99.00
Cat# BP7120b
Availability: 2 weeks
Bulk Size
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