|Other Accession||O54968, Q60795, NP_006155|
|Other Names||Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2, NRF2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 45-59 of HUMAN NFE2L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.|
|Cellular Location||Cytoplasm, cytosol Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.|
|Tissue Location||Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle|
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Provided below are standard protocols that you may find useful for product applications.
NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995).
Zhao,X., Stroke 38 (12), 3280-3286 (2007) Li,M.H., J. Biol. Chem. 282 (39), 28577-28586 (2007)
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