|Other Names||14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8152d was selected from the T232 region of human 14-3-3 protein zeta/delta. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|
|Cellular Location||Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes|
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Provided below are standard protocols that you may find useful for product applications.
14-3-3 protein zeta/delta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs.
Li,F.Q., J. Cell Biol. 181 (7), 1141-1154 (2008)Mateo,I., Eur. J. Neurol. 15 (3), 219-222 (2008)Li,Z., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 162-167 (2008)Powell,D.W., Mol. Cell. Biol. 23 (15), 5376-5387 (2003)Powell,D.W., J. Biol. Chem. 277 (24), 21639-21642 (2002)
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