|Other Names||Tyrosine-protein phosphatase non-receptor type 4, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1, PTPN4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8407a was selected from the Center region of human MEG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act at junctions between the membrane and the cytoskeleton.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton|
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Provided below are standard protocols that you may find useful for product applications.
MEG1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Hironaka, K., et al., J. Biol. Chem. 275(21):16167-16173 (2000).Gu, M., et al., Proc. Natl. Acad. Sci. U.S.A. 93(23):12980-12985 (1996).Gu, M., et al., J. Biol. Chem. 271(44):27751-27759 (1996).Gu, M.X., et al., Proc. Natl. Acad. Sci. U.S.A. 88(13):5867-5871 (1991).
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