|Other Names||Receptor-type tyrosine-protein phosphatase T, R-PTP-T, Receptor-type tyrosine-protein phosphatase rho, RPTP-rho, PTPRT, KIAA0283|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8420a was selected from the N-term region of human PTPrho . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in both signal transduction and cellular adhesion in the CNS.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
PTPrho is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system.
McAndrew, P.E., et al., J. Comp. Neurol. 391(4):444-455 (1998).Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996).McAndrew, P.E., et al., Brain Res. Mol. Brain Res. 56 (1-2), 9-21 (1998).Besco, J.A., et al., BMC Genomics 2 (1), 1 (2001).
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