|Other Names||Dual specificity protein phosphatase 15, VH1-related member Y, Vaccinia virus VH1-related dual-specific protein phosphatase Y, DUSP15, C20orf57, VHY|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8457a was selected from the N-term region of human DUSP15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (PubMed:22792334).|
|Tissue Location||Highly expressed in testis (PubMed:15138252). Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions (PubMed:22792334)|
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Provided below are standard protocols that you may find useful for product applications.
DUSP15 belongs to the non-receptor class of the protein-tyrosine phosphatase family. This protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase.
Alonso, A., et al., J. Biol. Chem. 279(31):32586-32591 (2004).
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