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DUSP16 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BY84
Clone Names 4021112
Peptide ID 4021112
Additional Information
Gene ID 80824
Other Names Dual specificity protein phosphatase 16, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8458b was selected from the C-term region of human DUSP16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP16
Synonyms KIAA1700, MKP7
Function Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Cellular Location Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles
Research Areas
Citations (0)

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DUSP16 is involved in the inactivation of MAP kinases. The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.


Katagiri, C., et al., J. Biol. Chem. 280(15):14716-14722 (2005).Hoornaert, I., et al., Oncogene 22(49):7728-7736 (2003).Masuda, K., et al., J. Biol. Chem. 278(34):32448-32456 (2003).Willoughby, E.A., et al., J. Biol. Chem. 278(12):10731-10736 (2003).Masuda, K., et al., J. Biol. Chem. 276(42):39002-39011 (2001).

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$ 99.00
Cat# BP8458b
Availability: In Stock
Bulk Size
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