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CTDSP2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14595
Other Accession Q53ZR2
Clone Names 4021303
Peptide ID 4021303
Additional Information
Gene ID 10106
Other Names Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4, SCP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8460b was selected from the C-term region of human CTDSP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NIF2, OS4, SCP2
Function Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Cellular Location Nucleus.
Tissue Location Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver
Research Areas
Citations (0)

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CTDSP2 is one of several small CTD phosphatases (SCP). It has been proposed that SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. In addition, expression of phosphatase CTDSP2 mRNA isenhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes, and CTDSP2 coamplifies with CDK4 in some primary sarcomas. CTDSP2 may contribute to the development of a subset of sarcomas.


Yeo, M., et al., J. Biol. Chem. 278(28):26078-26085 (2003).Su, Y.A., et al., Oncogene 15(11):1289-1294 (1997).Beutler, E., et al., Blood Cells Mol. Dis. 21(3):207-216 (1995).Su, Y.A., et al., Proc. Natl. Acad. Sci. U.S.A. 91(19):9121-9125 (1994).Su, Y.A., et al., Oncogene 15, 1290-1294 (1997) (): ().

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$ 99.00
Cat# BP8460b
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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