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CTDSP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9GZU7
Clone Names 4021304
Peptide ID 4021304
Additional Information
Gene ID 58190
Other Names Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8461a was selected from the N-term region of human CTDSP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NIF3, NLIIF, SCP1
Function Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Cellular Location Nucleus. Note=Colocalizes with RNA polymerase II
Tissue Location Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
Research Areas
Citations (0)

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CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.


Yeo, M., et al., Science 307(5709):596-600 (2005).Fernandes, A.O., et al., J. Neurosci. Res. 75(4):461-471 (2004).Yeo, M., et al., J. Biol. Chem. 278(28):26078-26085 (2003).Ma, X., et al., J. Hum. Genet. 47(3):140-145 (2002).Marquet, S., et al., Mamm. Genome 11(9):755-762 (2000).

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$ 99.00
Cat# BP8461a
Availability: In Stock
Bulk Size
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