|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, PPP3CB, CALNA2, CALNB, CNA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8464a was selected from the N-term region of human PPP3CB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CALNA2, CALNB, CNA2|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).|
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Provided below are standard protocols that you may find useful for product applications.
PPP3CB is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Katanosaka, Y., et al., J. Biol. Chem. 280(7):5764-5772 (2005).Bell, O., et al., Mol. Endocrinol. 19(2):516-526 (2005).Bennasser, Y., et al., Virology 303(1):174-180 (2002).Kissinger, C.R., et al., Nature 378(6557):641-644 (1995).Muramatsu, T., et al., Biochim. Biophys. Acta 1178(1):117-120 (1993).
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