|Other Names||Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8592a was selected from the N-term region of human ZMYND11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non- specifically to dsDNA (PubMed:24675531). Acts as a tumor- suppressor by repressing a transcriptional program essential for tumor cell growth.|
|Cellular Location||Nucleus Chromosome. Note=Associates with chromatin and mitotic chromosomes.|
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Provided below are standard protocols that you may find useful for product applications.
ZMYND11 is first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression.
Yu,B., Shao,Y., et.al., Exp. Cell Res. 315 (20), 3543-3553 (2009)Kurozumi,K., et.al., Genes Cells 3 (4), 257-264 (1998)
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