|Other Names||GDP-mannose 4, 6 dehydratase, GDP-D-mannose dehydratase, GMD, GMDS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose.|
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Provided below are standard protocols that you may find useful for product applications.
GDP-mannose 4,6-dehydratase (GMD; EC 220.127.116.11) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
Mungall, A.J., et al. Nature 425(6960):805-811(2003)Roos, C., et al. J. Biol. Chem. 277(5):3168-3175(2002)Eshel, R., et al. Cell. Immunol. 213(2):141-148(2001)
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