|Other Names||Glucocorticoid modulatory element-binding protein 2, GMEB-2, DNA-binding protein p79PIF, Parvovirus initiation factor p79, PIF p79, GMEB2, KIAA1269|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.|
|Cellular Location||Nucleus. Cytoplasm. Note=May be also cytoplasmic|
|Tissue Location||Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues|
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Provided below are standard protocols that you may find useful for product applications.
GMEB2 is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.
Lim, J., et al. Cell 125(4):801-814(2006)Kaul, S., et al. J. Biol. Chem. 277(15):12541-12549(2002)Deloukas, P., et al. Nature 414(6866):865-871(2001)Burnett, E., et al. J. Mol. Biol. 314(5):1029-1039(2001)Kaul, S., et al. Mol. Endocrinol. 14(7):1010-1027(2000)
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