|Calculated MW||31390 Da|
|Application & Usage||The peptide is used for blocking the antibody activity of ICAM-2. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C.|
|Other Names||Intercellular adhesion molecule 2, ICAM-2, Lymphocyte function-associated AG-1 counter-receptor, CD102, Icam2, Icam-2|
|Formulation||50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.|
|Reconstitution & Storage||-20 °C|
|Precautions||ICAM-2 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Co-localizes with RDX, EZR and MSN in microvilli.|
|Tissue Location||Expressed in endothelial cells and leukocytes. High levels found in lung|
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