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>   home   >   Products   >   Proteins   >   Polybromo-1D bromodomain 1 (23-156 aa) (GST-tagged), Human recombinant protein    

Polybromo-1D bromodomain 1 (23-156 aa) (GST-tagged), Human recombinant protein

Polybromo-1D bromodomain 1 (23-156 aa) (GST-tagged), Human recombinant

Product info
Primary Accession Q86U86
Calculated MW 42.8 kDa (23-156 aa + NT GST Tag)
Additional Info
Gene ID 55193
Gene Symbol PBRM1
Other Names MGC165155; PBRM1; MGC165156; BAF180; Protein Polybromo-1; BRG1-associated factor 180; hPB1; PB1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity BRM
Format Liquid
Storage -80°C; 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Citations (0)

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The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The PBRM1 gene encodes the bromodomain-containing protein Polybromo-1D (PBRM1). PBRM1 contains six bromodomains and is a component of the SWI/SNF complex, PBAF. PBAF is targeted to acetylated sites in chromatin by the PBRM1 bromodomains, where it plays a role in cell cycle regulation and tumor suppression. This product contains the bromodomain 1 region of PBRM1.


Xue Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:13015-13020(2000).
Horikawa I.,et al.DNA Seq. 13:211-215(2002).
Sekine I.,et al.Oncogene 24:2735-2738(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lemon B.,et al.Nature 414:924-928(2001).

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$ 175.00
$ 595.00
Cat# PBV11232r-20
Availability: 5-7days
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