Active D-2-Hydroxyglutaratate Dehydrogenase (D2HGDH), Recombinant
D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD
|Calculated MW||39 kDa|
|Other Names||D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD|
|Gene Source||Acidaminococcus fermentans|
|Sequence||Full-length his-tagged D2HGDH|
|Application Notes||Reconstitute in water to a concentration of 0.1-5 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.|
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Provided below are standard protocols that you may find useful for product applications.
D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays.
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