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>   home   >   Products   >   Proteins   >   Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant   

Cyclin-dependent kinase inhibitor 2A_TAT, Human Recombinant

p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16IN

Product info
Primary Accession P42771
Calculated MW 18 kDa
Additional Info
Gene ID 1029
Other Names p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;≥95%
Assay2&Purity2 HPLC;≥95%
Recombinant Yes
Sequence Full-length human Cyclin-dependent kinase inhibitor 2A and a 12-residue C-terminal TAT peptide (GYGRKKRRQRRR)
Target/Specificity Cyclin-dependent kinase inhibitor 2A-TAT
Application Notes Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
Format Dry powder
Storage -80°C;Lyophilized powder
Citations (0)

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Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of Cyclin-Dependent Kinase Inhibitor 2A steadily increases with age, and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the Cyclin-Dependent Kinase Inhibitor 2A gene is frequently found in melanomas, as well as in certain other types of cancer. TAT is a cell penetrating peptides (CPPs) and was shown to enable the introduction of nucleic acids into cells.

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$ 165.00
$ 685.00
Cat# PBV11463r-20
Availability: 5-7days
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