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Active Cathepsin D, Human Recombinant

Procathepsin D, CTSD

Product info
Primary Accession P07339
Calculated MW 45.1 kDa
Additional Info
Gene ID 1509
Other Names Procathepsin D, CTSD
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE;≥80%
Assay2&Purity2 N/A;≥80%
Recombinant Yes
Target/Specificity Cathepsin D
Application Notes Reconstitute to 1 mg/ml in water
Format Freeze-Dried
Storage -20°C;Freeze-dried from proprietary buffer
Citations (0)

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Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate active single-chain Cathepsin D; while in lysosomes, further processing by cysteine cathepsins B and L generates mature, active double-chain Cathepsin D. BioVision’s Active Human Cathepsin D is a proteolytically active, non-glycosylated enzyme expressed, purified and activated by proprietary methods.

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$ 180.00
$ 630.00
$ 995.00
Cat# PBV11473r-10
Availability: 5-7days
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