|Calculated MW||68 kDa|
|Other Names||V-set and immunoglobulin domain containing 4; Z39Ig; CRIg|
|Source||HEK 293 cells|
|Application Notes||Reconstitute in 1X PBS to the desired protein concentration.|
|Storage||-20°C;Lyophilized from 0.2 µm-filtered solution in PBS.|
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VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.
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