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Isocitrate Dehydrogenase 1 R132H mutant, Recombinant Human

Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H

Product info
Primary Accession O75874
Calculated MW 50.9 kDa
Additional Info
Gene ID 3417
Other Names Isocitrate dehydrogenase [NADP] cytoplasmic, R132H, IDH 1 R132H
Gene Source Human
Source E. Coli
Assay&Purity SDS-PAGE;≥90%
Recombinant Yes
Application Notes Reconstitute in deionized water to the final concentration 0.5 mg/ml and incubate the reconstituted protein at 25 °C for 15 minutes.
Format Lyophilized
Storage -20°C;N/A
Citations (0)

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Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors.

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$ 105.00
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$ 895.00
Cat# PBV11550r-10
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