Glyoxalase II (Glx II), Human Recombinant
Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2
|Calculated MW||32.4 kDa|
|Other Names||Hydroxyacylglutathione hydrolase, mitochondrial, HAGH1, GLO2|
|Storage||-20°C;30% glycerol, 50 mM Tris pH 7.4 and 150 mM NaCl|
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Provided below are standard protocols that you may find useful for product applications.
The glyoxalase system consists of Glyoxalase I (Glx I) and Glyoxalase II (Glx II) which is responsible for detoxifying α-ketoaldehydes such as the potent and cytotoxic methylglyoxal (MG). Glx I converts MG to S-D-lactoyl-glutathione (SLG). SLG is then hydrolyzed to D-lactate and reduced glutathione by Glx II. Glx II desensitizes cells to p53-dependent DNA damage-induced apoptosis. It also plays a role during development and in the pathogenesis of cancer and neurodegenerative diseases. Glyoxalase II may also be important in the regulation of spermatogenesis.
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