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hLIF Protein

Human Leukemia Inhibitory Factor, Recombinant,E. coli

  • WB - hLIF Protein PG10023-050
    human_LIF - Abgent human LIF activates ERK1 2 MAPK and STAT3 in 3T3-L1 cells.Cells were serum starved for 2 h and stimulated with 100 ng/ml of humanLIF(#PG10023) for 10 min. Cell proteins were resolved by SDS-PAGE and probed with anti-phospho-STAT3 and anti-phospho-ERK1/2.
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PrecautionshLIF Protein is for research use only and not for use in diagnostic or therapeutic procedures.
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Leukemia inhibitory factor (LIF) was identified by its ability to induce terminal differentiation in leukemic cells.1,2 LIF is a pleiotrophic factor with known actions in the immune system, the nervous system and the reproductive system.3,4 

In the nervous system it acts on cultured sympathetic neurons to direct a change in neurotransmitter expression from a noradrenergic to a cholinergic phenotype and regulates the expression of neuropeptide transmitters in these cells.5,6 
In the immune system LIF plays a key role in inflammation,7,8 with a pro-inflammatory role in rheumatoid arthritis,9 but also with proposed anti-inflammatory properties in lung inflammatory processes. 
In the reproductive system, LIF appears to play an important role in implantation and in the establishment of pregnancy.10,12 LIF acts as a trophic factor for oligodendrocytes and promotes astrocytic survival and differentiation.13,14 It exhibits activity towards spinal motor neurons and stimulate the biosynthesis of acetylcholine.6 

LIF also functions as a trophic factor for peripheral sensory neurons supporting their survival.15,16 LIF appears to be essential for injury-induced neuropeptide synthesis17 and can also stimulate the hypothalamic-pituitary-adrenal axis in response to stress and disease.18 LIF is used extensively in experimental biology because of its ability to induce embryonic stem cells to retain their totipotentiality.


1 . Brach, al.(1990)Leukemia4,646.
2 . Estrov, al.(1992)Leuk. Lymphoma 8,1.
3 . Gough, al.(1989)Cancer Cells. 1,77.
4 . Metcalf, D. (2003)Stem Cells 21,5.
5 . Zurn, A.D. and Werren, F.(1994)Dev. Biol. 163,309.
6 . Martinou, al.(1992)Neuron8,737.
7 . Gadient, R.A. and Patterson, P.H.(1999)Stem Cells 17,127.
8 . Patterson, P.H.(1994)Proc. Natl. Acad. Sci. U.S.A. 91,7833.
9 . Gabay, al.(1996)Clin. Exp. Immunol. 105, 260.
10 . Lass, al.(2001)Fertil. Steril. 76,1091.
11 . Robb, al.(2002)J. Reprod. Immunol. 57,129.
12 . Ledee Bataille, al.(2002)Hum. Reprod. 17,213.
13 . Vos, J.P. et al.(1996)Perspect. Dev. Neurobiol. 4,39.
14 . Butzkueven, H. et al.(2002)Nat. Med. 8,613.
15 . Horton, A.R. et al.(1996)Perspect. Dev. Neurobiol. 4,35.
16 . Murphy, M. et al.(1997)Prog. Neurobiol. 52,355.
17 . Rajan, al.(1995)Neuroreport6,2240.
18 . Akita, al.(1996)J. Clin. Endocrinol. Metab. 81,4170.

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$ 207.60
$ 247.20
Cat# PG10023-050
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