Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Proteins   >   hNT-4 Protein   

hNT-4 Protein

Human Neurotrophin-4, Recombinant,E. coli

  • WB - hNT-4 Protein PG10032-005
    human_NT-4 - Abgent human NT-4 induces activation of ERK1 2 MAPK in TrkB transfected HEK-293 cells.Cells were serum starved for 2 h, preincubated with or without 200 nM K252a as indicated and then stimulated with variousconcentrations of human NT-4 (#PG10032). Cell proteins were resolved by SDS-PAGE and probed with anti-phospho-ERK1/2.
Product Information
Additional Information
PrecautionshNT-4 Protein is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical, stellate and celiac ganglion,2T-cells3 and is synthesized by keratinocytes.4 

The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF.5 

The rat and human forms of NT-4 are 96% homologous. NT-4 has been shown to promote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons,6 to promote growth and remodeling of adult motor neuron innervation,7 to be anterograde survival factors for postsynaptic cells8 and to protect against apoptotic neuronal death.9 

The biological effects of NT-4 are mediated by two receptors: TrkB which is specific for NT-4 and BDNF, and p75 which binds all the neurotrophins.10


1 . Roux, al.(2002)Prog. Neurobiol. 67,203.
2 . Moalem, G. et al.(2000)J. Autoimmun. 15,331.
3 . Marconi, al.(2003)J. Invest. Dermatol. 121,1515.
4 . McDonald, al.(1991)Nature354,411.
5 . DeFazio, R. al. (2000)Neuroscience99,297.
6 . Belluardo, al.(2001)Mol. Cell Neurosci. 18,56.
7 . Spalding, al.(2002)Mol. Cell Neurosci. 19,485.
8 . Lobner, D. and Ali, C.(2002)Brain Res. 954,42.
9 . Teng, K.K. and Hempstead, B.L. (2004) Cell Mol. Life Sci. 61,35.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 181.20
$ 220.80
Cat# PG10032-005
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions