Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Peptides   >   Synthetic Peptides   >   MAGE - A2 (157 - 166)   

MAGE - A2 (157 - 166)

Synthetic Peptide

Product Information
Primary Accession P43356
Peptide ID 11100735
Calculated MW 1180.4 Da
Additional Information
Other Names Melanoma-associated antigen 2, Cancer/testis antigen 12, CT12, MAGE-2 antigen, MAGEA2, MAGE2, MAGEA2A
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAGE2, MAGEA2A
Function Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Cellular Location Nucleus. Nucleus, PML body.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes EMBL; L18920; AAA17729.1; -; Genomic_DNA EMBL; AK290443; BAF83132.1; -; mRNA EMBL; U82671; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471169; EAW99429.1; -; Genomic_DNA EMBL; BC108720; AAI08721.1; -; mRNA EMBL; BC112158; AAI12159.1; -; mRNA EMBL; BC112160; AAI12161.1; -; mRNA CCDS; CCDS76046.1; - CCDS; CCDS76049.1; - PIR; I68889; I68889 RefSeq; NP_001269430.1; NM_001282501.1 RefSeq; NP_001269431.1; NM_001282502.1 RefSeq; NP_001269433.1; NM_001282504.1 RefSeq; NP_001269434.1; NM_001282505.1 RefSeq; NP_001308329.1; NM_001321400.1 RefSeq; NP_001308330.1; NM_001321401.1 RefSeq; NP_001308331.1; NM_001321402.1 RefSeq; NP_001308332.1; NM_001321403.1 RefSeq; NP_001308333.1; NM_001321404.1 RefSeq; NP_005352.1; NM_005361.3 RefSeq; NP_705692.1; NM_153488.4 RefSeq; NP_786884.1; NM_175742.2 RefSeq; NP_786885.1; NM_175743.2 RefSeq; XP_016884895.1; XM_017029406.1 RefSeq; XP_016885008.1; XM_017029519.1 UniGene; Hs.534597; - UniGene; Hs.713061; - UniGene; Hs.736992; - ProteinModelPortal; P43356; - SMR; P43356; - BioGrid; 110275; 6 BioGrid; 129334; 13 DIP; DIP-61231N; - IntAct; P43356; 27 STRING; 9606.ENSP00000359307; - iPTMnet; P43356; - PhosphoSitePlus; P43356; - BioMuta; MAGEA2; - DMDM; 1170856; - EPD; P43356; - MaxQB; P43356; - PaxDb; P43356; - PeptideAtlas; P43356; - PRIDE; P43356; - ProteomicsDB; 55618; - DNASU; 266740; - DNASU; 4101; - Ensembl; ENST00000331220; ENSP00000333487; ENSG00000183305 Ensembl; ENST00000370293; ENSP00000359316; ENSG00000183305 Ensembl; ENST00000595583; ENSP00000470872; ENSG00000268606 Ensembl; ENST00000598543; ENSP00000469919; ENSG00000268606 Ensembl; ENST00000611557; ENSP00000480738; ENSG00000268606 Ensembl; ENST00000611674; ENSP00000480491; ENSG00000268606 Ensembl; ENST00000620710; ENSP00000484290; ENSG00000268606 Ensembl; ENST00000623438; ENSP00000485391; ENSG00000268606 Ensembl; ENST00000623806; ENSP00000485541; ENSG00000268606 GeneID; 266740; - GeneID; 4101; - KEGG; hsa:266740; - KEGG; hsa:4101; - UCSC; uc004fgg.3; human CTD; 266740; - CTD; 4101; - DisGeNET; 266740; - DisGeNET; 4101; - EuPathDB; HostDB:ENSG00000183305.13; - EuPathDB; HostDB:ENSG00000268606.5; - GeneCards; MAGEA2; - GeneCards; MAGEA2B; - HGNC; HGNC:6800; MAGEA2 HGNC; HGNC:19340; MAGEA2B MIM; 300173; gene MIM; 300549; gene neXtProt; NX_P43356; - OpenTargets; ENSG00000183305; - PharmGKB; PA30546; - eggNOG; KOG4562; Eukaryota eggNOG; ENOG4111S70; LUCA GeneTree; ENSGT00760000118824; - HOGENOM; HOG000231161; - HOVERGEN; HBG006315; - InParanoid; P43356; - OMA; ISGEPHI; - OrthoDB; EOG091G0TJ0; - PhylomeDB; P43356; - TreeFam; TF328505; - GeneWiki; MAGEA2; - PRO; PR:P43356; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000183305; - CleanEx; HS_MAGEA2; - ExpressionAtlas; P43356; baseline and differential Genevisible; P43356; HS GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0016605; C:PML body; IDA:UniProtKB GO; GO:0042826; F:histone deacetylase binding; IDA:UniProtKB GO; GO:0070491; F:repressing transcription factor binding; IDA:UniProtKB GO; GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB GO; GO:0044257; P:cellular protein catabolic process; IMP:UniProtKB GO; GO:0090398; P:cellular senescence; IDA:UniProtKB GO; GO:1901984; P:negative regulation of protein acetylation; IDA:UniProtKB GO; GO:0033234; P:negative regulation of protein sumoylation; IDA:UniProtKB GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB GO; GO:0051443; P:positive regulation of ubiquitin-protein transferase activity; IMP:UniProtKB GO; GO:0072331; P:signal transduction by p53 class mediator; IDA:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR037445; MAGE InterPro; IPR021072; MAGE_N InterPro; IPR002190; MHD_dom PANTHER; PTHR11736; PTHR11736; 1 Pfam; PF01454; MAGE; 2 Pfam; PF12440; MAGE_N; 1 SMART; SM01373; MAGE; 1 SMART; SM01392; MAGE_N; 1 PROSITE; PS50838; MAGE; 1 1: Evidence at protein level; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor antigen; Ubl conjugation pathway CHAIN 1 314 Melanoma-associated antigen 2 /FTId=PRO_0000156702 DOMAIN 109 308 MAGE. {ECO:0000255|PROSITE- ProRule:PRU00127} COMPBIAS 40 43 Poly-Ser MOD_RES 64 64 Phosphoserine {ECO:0000250|UniProtKB:P43355} MUTAGEN 170 170 V->D: Improves ability to bind to HLA-A1 SEQUENCE 314 AA; 35055 MW; 844F16335A2BECE7 CRC64; MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQQTAS SSSTLVEVTL GEVPAADSPS PPHSPQGASS FSTTINYTLW RQSDEGSSNQ EEEGPRMFPD LESEFQAAIS RKMVELVHFL LLKYRAREPV TKAEMLESVL RNCQDFFPVI FSKASEYLQL VFGIEVVEVV PISHLYILVT CLGLSYDGLL GDNQVMPKTG LLIIVLAIIA IEGDCAPEEK IWEELSMLEV FEGREDSVFA HPRKLLMQDL VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHT LKIGGEPHIS YPPLHERALR EGEE
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.
Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# SP2473b
Availability: Inquire
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions