|Calculated MW||2272.57 Da|
|Other Names||Prolactin-releasing peptide, PrRP, Prolactin-releasing hormone, Prolactin-releasing peptide PrRP31, Prolactin-releasing peptide PrRP20, Prlh, Prh|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.|
|Tissue Location||Widely expressed, with highest levels in medulla oblongata and hypothalamus. EMBL; AB015418; BAA29026.1; -; mRNA EMBL; AB040613; BAB33377.1; -; Genomic_DNA EMBL; AF521930; AAM82154.1; -; mRNA PIR; JC7607; JC7607 RefSeq; NP_071558.1; NM_022222.1. [P81278-1] RefSeq; XP_006245540.1; XM_006245478.3. [P81278-1] UniGene; Rn.91303; - STRING; 10116.ENSRNOP00000026912; - PaxDb; P81278; - PRIDE; P81278; - Ensembl; ENSRNOT00000026912; ENSRNOP00000026912; ENSRNOG00000019871. [P81278-1] GeneID; 63850; - KEGG; rno:63850; - UCSC; RGD:628634; rat. [P81278-1] CTD; 51052; - RGD; 628634; Prlh eggNOG; ENOG410J49T; Eukaryota eggNOG; ENOG4111800; LUCA GeneTree; ENSGT00390000005489; - HOGENOM; HOG000115720; - HOVERGEN; HBG004601; - InParanoid; P81278; - KO; K05269; - OMA; RAHQHSM; - OrthoDB; 1486353at2759; - PhylomeDB; P81278; - Reactome; R-RNO-375276; Peptide ligand-binding receptors PRO; PR:P81278; - Proteomes; UP000002494; Chromosome 9 Bgee; ENSRNOG00000019871; Expressed in 6 organ(s), highest expression level in testis Genevisible; P81278; RN GO; GO:0005737; C:cytoplasm; IDA:MGI GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell GO; GO:0005179; F:hormone activity; TAS:RGD GO; GO:0005184; F:neuropeptide hormone activity; IMP:RGD GO; GO:0005148; F:prolactin receptor binding; TAS:RGD GO; GO:0031861; F:prolactin-releasing peptide receptor binding; IMP:RGD GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl GO; GO:0007631; P:feeding behavior; IMP:RGD GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl GO; GO:0002023; P:reduction of food intake in response to dietary excess; IMP:MGI GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl GO; GO:0009749; P:response to glucose; IEA:Ensembl GO; GO:0032868; P:response to insulin; IEA:Ensembl GO; GO:0001894; P:tissue homeostasis; IEA:Ensembl InterPro; IPR026194; PrRP PANTHER; PTHR17206; PTHR17206; 1 Pfam; PF15172; Prolactin_RP; 1 2: Evidence at transcript level; Alternative splicing; Amidation; Cleavage on pair of basic residues; Complete proteome; Hormone; Reference proteome; Secreted; Signal SIGNAL 1 21 PEPTIDE 22 52 Prolactin-releasing peptide PrRP31 /FTId=PRO_0000022147 PEPTIDE 33 52 Prolactin-releasing peptide PrRP20 /FTId=PRO_0000022148 PROPEP 57 83 /FTId=PRO_0000022149 MOD_RES 52 52 Phenylalanine amide. VAR_SEQ 33 83 TPDINPAWYTGRGIRPVGRFGRRRATPRDVTGLGQLSCLPL DGRTKFSQRG -> SECLTYGKQPLTSFHPFTSQMPP (in isoform 2). /FTId=VSP_004370 SEQUENCE 83 AA; 9215 MW; D0C75A264EEE4F29 CRC64; MALKTWLLCL LLLSLVLPGA SSRAHQHSME TRTPDINPAW YTGRGIRPVG RFGRRRATPR DVTGLGQLSC LPLDGRTKFS QRG|
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