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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-SLC6A4 Antibody   

Anti-SLC6A4 Antibody

     
  • IHC - Anti-SLC6A4 Antibody ABO11018
    Anti-SLC6A4 antibody, ABO11018, IHC(P)IHC(P): Rat Brain Tissue
  • WB - Anti-SLC6A4 Antibody ABO11018
    Anti-SLC6A4 antibody, ABO11018, Western blottingWB: Rat Brain Tissue Lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P31652
Host Rabbit
Reactivity Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Sodium-dependent serotonin transporter(SLC6A4) detection. Tested with WB, IHC-P in Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 25553
Other Names Sodium-dependent serotonin transporter, SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4, Slc6a4
Calculated MW 70172 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Rat
Subcellular Localization Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin. function as homooligomeric forms (By similarity). .
Protein Name Sodium-dependent serotonin transporter
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of rat SLC6A4 (7-24aa NSQKVLSECKDREDCQEN), different from the related mouse sequence by one amino acid.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Slc6a4
Function Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (PubMed:11709063). Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity) {ECO:0000250|UniProtKB:P31645, ECO:0000269|PubMed:11709063, ECO:0000269|PubMed:16870614}
Research Areas
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Background

SLC6A4(Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

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$ 280.00
Cat# ABO11018
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