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Anti-Glutathione Peroxidase 2 Antibody
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- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | P18283 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Glutathione peroxidase 2(GPX2) detection. Tested with WB, IHC(P), ICC in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 2877 |
|---|---|
| Other Names | Glutathione peroxidase 2, GPx-2, GSHPx-2, 1.11.1.9, Gastrointestinal glutathione peroxidase, Glutathione peroxidase-gastrointestinal, GPx-GI, GSHPx-GI, Glutathione peroxidase-related protein 2, GPRP-2, GPX2 |
| Calculated MW | 21954 MW KDa |
| Application Details | Immunocytochemistry , 0.5-1 µg/ml, Human, Rat Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
| Subcellular Localization | Cytoplasm. Mainly cytoplasmic. |
| Tissue Specificity | Mostly in liver and gastrointestinal tract, not found in heart or kidney. |
| Protein Name | Glutathione peroxidase 2(GPx-2) |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Glutathione Peroxidase 2(44-60aa TRDFTQLNELQCRFPRR), different from the related mouse sequence by two amino acids and from related rat sequence by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the glutathione peroxidase family. |
| Name | GPX2 {ECO:0000303|Ref.9, ECO:0000312|HGNC:HGNC:4554} |
|---|---|
| Function | Catalyzes the reduction of hydroperoxides in a glutathione- dependent manner thus regulating cellular redox homeostasis (PubMed:8428933, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:8428933, PubMed:36608588). Cannot reduce phosphatidycholine hydroperoxide (PubMed:8428933). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Mostly in liver and gastrointestinal tract, not found in heart or kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GPX2(glutathione peroxidase 2(gastrointestinal)) also known as GSHPX-GI or GLUTATHIONE PEROXIDASE, GASTROINTESTINAL, is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The GPX2 gene is mapped to chromosome 14 by Southern analysis of human/hamster somatic cell hybrids. Gpx6 is aselenoprotein in humans with cysteine-containing homologues in rodents.Â
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