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Anti-Transferrin Receptor 2 Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9JKX3 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Transferrin receptor protein 2(TFR2) detection. Tested with WB in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 50765 |
|---|---|
| Other Names | Transferrin receptor protein 2, TfR2, Tfr2, Trfr2 |
| Calculated MW | 88402 MW KDa |
| Application Details | Western blot, 0.1-0.5 µg/ml, Mouse, Rat |
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart. |
| Protein Name | Transferrin receptor protein 2 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of mouse Transferrin Receptor 2(1-15aa MEQRWGLLRRVQQWS), different from the related rat sequence by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Name | Tfr2 |
|---|---|
| Synonyms | Trfr2 |
| Function | Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TFR2(Transferrin receptor protein 2), is a protein that in humans is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated(PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. By radiation hybrid analysis, Kawabata et al.(1999) mapped the TFR2 gene to chromosome 7q22.The majority of hepatic iron uptake under normal circumstances is transferrin-mediated. However, expression of TFRC in hepatocytes, as in other nonreticuloendothelial cell types, is downregulated in response to increased intracellular iron. As a consequence, TFRC expression in liver is undetectable in hereditary hemochromatosis patients with hepatic iron loading. Nonetheless, hepatic iron loading in hemochromatosis patients is progressive. Fleming et al.(2000) provided support for a mechanism that involves the uptake of transferrin-bound iron by TFR2.
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