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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Claudin 6 Antibody   

Anti-Claudin 6 Antibody

     
  • WB - Anti-Claudin 6 Antibody ABO11326
    Anti-Claudin 6 antibody, ABO11326, Western blottingLane 1: HELA Cell LysateLane 2: SMMC Cell Lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P56747
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Claudin-6(CLDN6) detection. Tested with WB in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 9074
Other Names Claudin-6, Skullin, CLDN6
Calculated MW 23292 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. .
Protein Name Claudin-6
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Claudin 6(204-220aa APAISRGPSEYPTKNYV).
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the claudin family.
Protein Information
Name CLDN6
Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Cellular Location Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z262}. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines
Research Areas
Citations (0)

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Background

Claudin-6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

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$ 240.00
Cat# ABO11326
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