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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Glucose Transporter 8 Antibody   

Anti-Glucose Transporter 8 Antibody

     
  • WB - Anti-Glucose Transporter 8 Antibody ABO11477
    Anti-Glucose Transporter 8 antibody, ABO11477, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Human Placenta Tissue Lysate
  • IHC - Anti-Glucose Transporter 8 Antibody ABO11477
    Anti-Glucose Transporter 8 antibody, ABO11477, IHC(P)IHC(P): Rat Kidney Tissue
  • IHC - Anti-Glucose Transporter 8 Antibody ABO11477
    Anti-Glucose Transporter 8 antibody, ABO11477, IHC(P)IHC(P): Human Placenta Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9JIF3
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 8(SLC2A8) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 56017
Other Names Solute carrier family 2, facilitated glucose transporter member 8, Glucose transporter type 8, GLUT-8, Glucose transporter type X1, Slc2a8, Glut8, GlutX1
Calculated MW 51508 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane. .
Tissue Specificity Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle.
Protein Name Solute carrier family 2, facilitated glucose transporter member 8
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of mouse Glucose Transporter 8(461-477aa ETKGRTLEQVTAHFEGR), different from the related rat sequence by one amino acid, and from the related human sequence by two amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Slc2a8
Synonyms Glut8, GlutX1
Function Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity) Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane.
Tissue Location Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle
Research Areas
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Background

Solute carrier family 2, facilitated glucose transporter member 8, also known as SLC2A8, is the eighth member of glucose transporter superfamily. It is characterized by the presence of two leucine residues in its N-terminal intracellular domain, which influences intracellular trafficking. This gene is mapped to 9q33.3. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. It may act as the insulin-regulated facilitative glucose transporter. This gene binds cytochalasin B in a glucose-inhibitable manner. The binds seems to be a dual-specific sugar transporter as it is inhibitable by fructose.

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$ 280.00
Cat# ABO11477
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