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Anti-PON1 Antibody

     
  • WB - Anti-PON1 Antibody ABO11563
    Anti-PON1 antibody, ABO11563, All Western blottingAll lanes: Anti-PON1(ABO11563) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 40ugLane 2: Rat Lung Tissue Lysate at 40ugLane 3: Human Placenta Tissue Lysate at 40ugLane 4: Rat Testis Tissue Lysate at 40ugLane 5: HELA Whole Cell Lysate at 40ugLane 6: HEPA Whole Cell Lysate at 40ugLane 7: A549 Whole Cell Lysate at 40ugLane 8: JURKAT Whole Cell Lysate at 40ugLane 9: SKOV Whole Cell Lysate at 40ugPredicted bind size: 40KDObserved bind size: 40KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P27169
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Serum paraoxonase/arylesterase 1(PON1) detection. Tested with WB in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 5444
Other Names Serum paraoxonase/arylesterase 1, PON 1, 3.1.1.2, 3.1.1.81, 3.1.8.1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON
Calculated MW 39731 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Secreted, extracellular space.
Tissue Specificity Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. .
Protein Name Serum paraoxonase/arylesterase 1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human PON1(186-201aa FLDPYLQSWEMYLGLA), different from the related mouse and rat sequences by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the paraoxonase family.
Protein Information
Name PON1
Synonyms PON
Function Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Cellular Location Secreted, extracellular space.
Tissue Location Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas
Research Areas
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Background

Serum paraoxonase/arylesterase 1(PON1), also known as aromatic esterase 1, is an enzyme that in humans is encoded by the PON1 gene. It is mapped to 7q21.3. This gene has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1(paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein(HDL). The PON1 gene is activated by PPAR-gamma, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.

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$ 240.00
Cat# ABO11563
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