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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti-TNFAIP8L3 Antibody   

Anti-TNFAIP8L3 Antibody

     
  • IHC - Anti-TNFAIP8L3 Antibody ABO11567
    Anti-TNFAIP8L3 antibody, ABO11567, IHC(P)IHC(P): Human Intestinal Cancer Tissue
  • IHC - Anti-TNFAIP8L3 Antibody ABO11567
    Anti-TNFAIP8L3 antibody, ABO11567, IHC(P)IHC(P): Human Mammary Cancer Tissue
  • WB - Anti-TNFAIP8L3 Antibody ABO11567
    Anti-TNFAIP8L3 antibody, ABO11567, All Western blottingAll lanes: Anti-TNFAIP8L3(ABO11567) at 0.5ug/mlLane 1: MCF-7 Whole Cell Lysate at 40ugLane 2: SW620 Whole Cell Lysate at 40ugLane 3: COS7 Whole Cell Lysate at 40ugLane 4: SKOV Whole Cell Lysate at 40ugLane 5: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 33KDObserved bind size: 33KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q5GJ75
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Tumor necrosis factor alpha-induced protein 8-like protein 3(TNFAIP8L3) detection. Tested with WB, IHC-P in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 388121
Other Names Tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3, TNFAIP8L3, TIPE3
Calculated MW 32659 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat
Western blot, 0.1-0.5 µg/ml, Human
Protein Name Tumor necrosis factor alpha-induced protein 8-like protein 3
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human TNFAIP8L3(273-292aa RPNLKRICEGINKLLDEKVL), different from the related mouse and rat sequences by two amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the TNFAIP8 family.
Protein Information
Name TNFAIP8L3
Synonyms TIPE3
Function Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
Cellular Location Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane {ECO:0000250|UniProtKB:Q3TBL6}
Tissue Location Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044).
Research Areas
Citations (0)

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Background

TNFAIP8L3 belongs to the TNFAIP8 family. It acts as a negative mediator of apoptosis and may play a role in tumor progression. This gene suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

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$ 280.00
Cat# ABO11567
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