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Anti-sTNFsR II Antibody

     
  • WB - Anti-sTNFsR II Antibody ABO12203
    Anti- TNF Receptor II Picoband antibody, ABO12203, Western blottingAll lanes: Anti TNF Receptor II (ABO12203) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: Mouse Thymus Tissue Lysate at 50ugPredicted bind size: 75KDObserved bind size: 75KD
  • IHC - Anti-sTNFsR II Antibody ABO12203
    Anti- TNF Receptor II Picoband antibody, ABO12203, IHC(P)IHC(P): Mouse Thymus Tissue
  • IHC - Anti-sTNFsR II Antibody ABO12203
    Anti- TNF Receptor II Picoband antibody, ABO12203, IHC(P)IHC(P): Rat Spleen Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P25119
Host Rabbit
Reactivity Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) detection. Tested with WB, IHC-P in Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Other Names Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b, Tnfrsf1b, Tnfr-2, Tnfr2
Calculated MW 50320 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Mouse, Rat
Subcellular Localization Membrane; Single-pass type I membrane protein.
Protein Name Tumor necrosis factor receptor superfamily member 1B
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of mouse TNF Receptor II (296-324aa QRDAKVPHVPDEKSQDAVGLEQQHLLTTA), different from the related human sequence by eleven amino acids, and from the related rat sequence by six amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Tnfrsf1b
Synonyms Tnfr-2, Tnfr2
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein EMBL; M60469; AAA39752.1; -; mRNA EMBL; M59378; AAA40463.1; -; mRNA EMBL; Y14619; CAA74969.1; -; Genomic_DNA EMBL; Y14620; CAA74969.1; JOINED; Genomic_DNA EMBL; Y14621; CAA74969.1; JOINED; Genomic_DNA EMBL; Y14622; CAA74969.1; JOINED; Genomic_DNA EMBL; Y14679; CAA74969.1; JOINED; Genomic_DNA EMBL; Y14623; CAA74969.1; JOINED; Genomic_DNA EMBL; U39488; AAA85021.1; -; Genomic_DNA EMBL; X87128; CAA60618.1; -; Genomic_DNA CCDS; CCDS18914.1; - PIR; B38634; B38634 RefSeq; NP_035740.2; NM_011610.3 UniGene; Mm.235328; - ProteinModelPortal; P25119; - SMR; P25119; - BioGrid; 204250; 4 DIP; DIP-60902N; - IntAct; P25119; 4 MINT; P25119; - STRING; 10090.ENSMUSP00000030336; - PhosphoSitePlus; P25119; - SwissPalm; P25119; - EPD; P25119; - PaxDb; P25119; - PeptideAtlas; P25119; - PRIDE; P25119; - Ensembl; ENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599 GeneID; 21938; - KEGG; mmu:21938; - UCSC; uc008vrt.1; mouse CTD; 7133; - MGI; MGI:1314883; Tnfrsf1b eggNOG; ENOG410IJ06; Eukaryota eggNOG; ENOG410YPQW; LUCA GeneTree; ENSGT00760000119204; - HOGENOM; HOG000132845; - HOVERGEN; HBG054237; - InParanoid; P25119; - KO; K05141; - OMA; NCVIMTQ; - OrthoDB; EOG091G03XW; - PhylomeDB; P25119; - TreeFam; TF331157; - Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway Reactome; R-MMU-5669034; TNFs bind their physiological receptors Reactome; R-MMU-6798695; Neutrophil degranulation ChiTaRS; Tnfrsf1b; mouse PRO; PR:P25119; - Proteomes; UP000000589; Chromosome 4 Bgee; ENSMUSG00000028599; - ExpressionAtlas; P25119; baseline and differential Genevisible; P25119; MM GO; GO:0030424; C:axon; ISO:MGI GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0016020; C:membrane; IDA:MGI GO; GO:0045121; C:membrane raft; IDA:BHF-UCL GO; GO:0043025; C:neuronal cell body; ISO:MGI GO; GO:0005634; C:nucleus; ISO:MGI GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI GO; GO:0043196; C:varicosity; ISO:MGI GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IPI:MGI GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI GO; GO:0007568; P:aging; IEA:Ensembl GO; GO:0003176; P:aortic valve development; IGI:BHF-UCL GO; GO:0008283; P:cell proliferation; TAS:MGI GO; GO:0007166; P:cell surface receptor signaling pathway; IMP:MGI GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:MGI GO; GO:0006955; P:immune response; ISO:MGI GO; GO:0006954; P:inflammatory response; IMP:MGI GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:MGI GO; GO:0007275; P:multicellular organism development; IBA:GO_Central GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IGI:BHF-UCL GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central GO; GO:0003332; P:negative regulation of extracellular matrix constituent secretion; IGI:BHF-UCL GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI GO; GO:1902339; P:positive regulation of apoptotic process involved in morphogenesis; IGI:BHF-UCL GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; ISO:MGI GO; GO:0003177; P:pulmonary valve development; IGI:BHF-UCL GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central GO; GO:0050779; P:RNA destabilization; IMP:MGI CDD; cd10577; TNFRSF1B; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020411; TNFR_1B InterPro; IPR033996; TNFRSF1B_N Pfam; PF00020; TNFR_c6; 2 PRINTS; PR01919; TNFACTORR1B SMART; SM00208; TNFR; 4 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 3 2: Evidence at transcript level; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 22 CHAIN 23 474 Tumor necrosis factor receptor superfamily member 1B /FTId=PRO_0000034550 TOPO_DOM 23 258 Extracellular. TRANSMEM 259 288 Helical. TOPO_DOM 289 474 Cytoplasmic. REPEAT 39 77 TNFR-Cys 1 REPEAT 78 119 TNFR-Cys 2 REPEAT 120 164 TNFR-Cys 3 REPEAT 165 203 TNFR-Cys 4 MOD_RES 331 331 Phosphoserine {ECO:0000250|UniProtKB:P20333} CARBOHYD 30 30 O-linked (GalNAc...) threonine {ECO:0000250|UniProtKB:P20333} CARBOHYD 69 69 N-linked (GlcNAc...) asparagine CARBOHYD 195 195 N-linked (GlcNAc...) asparagine CARBOHYD 208 208 O-linked (GalNAc...) threonine {ECO:0000250|UniProtKB:P20333} CARBOHYD 224 224 O-linked (GalNAc...) threonine {ECO:0000250|UniProtKB:P20333} DISULFID 40 54 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 55 68 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 58 76 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 79 94 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 97 111 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 101 119 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 121 127 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 136 145 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 139 163 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 166 181 {ECO:0000255|PROSITE-ProRule:PRU00206} CONFLICT 78 78 D -> DSDTVCAD (in Ref. 3; CAA74969) CONFLICT 102 102 T -> S (in Ref. 3; CAA74969) CONFLICT 108 108 I -> T (in Ref. 3; CAA74969) CONFLICT 283 283 I -> F (in Ref. 3; CAA74969) CONFLICT 331 331 S -> SS (in Ref. 3; CAA74969) CONFLICT 360 360 F -> S (in Ref. 3; CAA74969) CONFLICT 436 436 C -> Y (in Ref. 3; CAA74969) SEQUENCE 474 AA; 50320 MW; 462EAE398C4D6563 CRC64; MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP LGVPDMGMKP SQAGWFDQIA VKVA
Research Areas
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Background

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

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$ 280.00
Cat# ABO12203
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