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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-CYP24A1 Picoband Antibody   

Anti-CYP24A1 Picoband Antibody

     
  • WB - Anti-CYP24A1 Picoband Antibody ABO12234
    Anti- CYP24A1 Picoband antibody, ABO12234, Western blottingAll lanes: Anti CYP24A1 (ABO12234) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 50ugLane 2: Rat Lung Tissue Lysate at 50ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: 22RV1 Whole Cell Lysate at 40ugLane 5: A431 Whole Cell Lysate at 40ugLane 6: HEPA Whole Cell Lysate at 40ugPredicted bind size: 59KDObserved bind size: 59KD
  • IHC - Anti-CYP24A1 Picoband Antibody ABO12234
    Anti- CYP24A1 Picoband antibody, ABO12234, IHC(P)IHC(P): Rat Kidney Tissue
  • IHC - Anti-CYP24A1 Picoband Antibody ABO12234
    Anti- CYP24A1 Picoband antibody, ABO12234, IHC(P)IHC(P): Mouse Kidney Tissue
  • IHC - Anti-CYP24A1 Picoband Antibody ABO12234
    Anti- CYP24A1 Picoband antibody, ABO12234, IHC(P)IHC(P): Human Pancreatic Cancer Tissue
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q07973
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 1591
Other Names 1, 25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 24-OHase, Vitamin D(3) 24-hydroxylase, 1.14.15.16, Cytochrome P450 24A1, Cytochrome P450-CC24, CYP24A1, CYP24
Calculated MW 58875 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Mitochondrion.
Protein Name 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human CYP24A1 recombinant protein (Position: E153-R514). Human CYP24A1 shares 86.2% amino acid (aa) sequence identity with both mouse and rat CYP24A1.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name CYP24A1
Synonyms CYP24
Function Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Cellular Location Mitochondrion.
Research Areas
Citations (0)

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Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. And this mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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$ 280.00
Cat# ABO12234
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