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Caspase-2 Antibody

Rabbit Polyclonal Antibody

  • WB - Caspase-2 Antibody ABV10019
    Western blot analysis of caspase-2 in untreated (Lane 1,2) and treated (Lane 3,4) cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29594
Other Accession D28492
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50661 Da
Additional Information
Gene ID 12366
Positive Control Western Blot: Jurkat cell lysate, treated and untreated. IHC: Placenta tissue.
Application & Usage Western blotting (1-2 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Detects the full length and small subunit of caspase-2. In human samples, it also detects a 30 kDa intermeadiate fragment
Other Names CASP-2, NEDD-2, NEDD2, ICH1, ICH-1L/1S, ICH-1L, EC
Target/Specificity Caspase-2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp2
Synonyms Ich1, Nedd-2, Nedd2
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. May be important in multistep carcinogenesis.
Tissue Location High level expression seen in the embryonic CNS, liver, lung, kidney, small intestine, and hair follicles of vibrissae. Moderate expression seen in the skin, oral mucosa, skeletal muscle, submandibular gland and thymus. In the adult, it is highly expressed in spleen, lung and kidney. Moderately in the brain, heart, testis, liver. Low levels in the thymus, skeletal muscle, ovary and gut
Research Areas
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Caspases play a key role in apoptosis. Similar as other caspases, caspase-2 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-2 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named ICH-1S. Over expression of ICH-1L induces apoptosis, while over expression of ICH-1S suppresses Rat-1 cell death induced by serum deprivation.

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$ 245.00
Cat# ABV10019
(40 western blots)
Availability: 5-7days
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