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Caspase-7 (Active) Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IP
Primary Accession P55210
Other Accession BAG61059
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 34277 Da
Additional Information
Gene ID 840
Application & Usage Western blotting (0.5-4 µg/ml), immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The antibody detects only the large subunit of cleaved caspase-7. The antibody does not recognize full length of caspase-7 or other caspases.

Other Names CASP7, CASP-7, ICE-LAP3, CMH-1, MCH3, EC 3.4.22.60
Target/Specificity Caspase-7 (Active)
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-Active caspase-7 antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-7 (Active) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP7
Synonyms MCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
Research Areas
Citations (0)

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Background

Caspase-7 has been identified as a major contributor to the execution of apoptosis. Caspase-7 is cleaved by many enzymes, including caspase-3, -6, -8, -9 and granzyme B. Active caspase-7 consists of a heterotetramer of two large and two small subunits. As an effector caspase, caspase-7 cleaves many of the same substrates as caspase-3, including poly (ADP-ribose) polymerase (PARP). The active caspase-7 antibody provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells.

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$ 89.00
$ 385.00
Cat# ABV10118-30
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