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>   home   >   Products   >   Primary Antibodies   >   Perforin Antibody (Clone δG9)   

Perforin Antibody (Clone δG9)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14222
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG2b
Clone Names δG9
Calculated MW 61377 Da
Additional Information
Gene ID 5551
Application & Usage Immunoprecipitation (2-8 µg/ml), Flow cytometry (2-8 µg/ml), Immunohistochemistry (2-8 µg/ml for both frozen and paraffin sections), Immunocytochemistry (2-8 µg/ml),. However, the optimal conditions should be determined individually. Recognizes the 70 kDa perforin in human and primate.
Other Names Perforin-1, P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, PFP
Target/Specificity Perforin
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (1 mg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM thimerosal and 50% glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPerforin Antibody (Clone δG9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRF1
Synonyms PFP
Function Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Cellular Location Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes
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Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting XD8+ cytotoxic cells upon activation.

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$ 295.00
Cat# ABV10153
(40 western blots)
Availability: 5-7days
Bulk Size
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