|Calculated MW||129383 Da|
|Positive Control||TSP-1 purified protein|
|Application & Usage||Western blot: 1:200 (This information is only intended as a guide. The optimal dilutions must be determined by the user.)|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TSP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).|
|Cellular Location||Endoplasmic reticulum. Sarcoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. It has also been used as a potential regulator of tumor growth and metastasis. TSP expression is highly regulated by different hormones and cytokines and is developmentally controlled. TSP stimulates the growth of vascular smooth muscle cells and human foreskin fibroblasts. A combination of IFN-gamma and TNF-alpha inhibits TSP production in these cells.
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