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TCTN3 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8R2Q6 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64824 Da |
| Gene ID | 67590 |
|---|---|
| Positive Control | Rat kidney tissue lysate |
| Application & Usage | The antibody can be used in Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. |
| Other Names | Tectonic-3, Tctn3, Tect3 |
| Target/Specificity | TCTN3 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-TCTN3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | TCTN3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tctn3 |
|---|---|
| Synonyms | Tect3 |
| Function | Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
TCTN3 belongs to the Tectonic protein family that regulate the Hedgehog (Hh)-signaling pathway. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is required for the formation of most ventral cell types and for full Hh pathway activation.
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