|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||73954 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml) and in immunoprecipitation and Immunohistochemistry. However, the optimal conditions should be determined individually. Rat kidney cell lysate can be used as a positive control.|
|Other Names||FAF1 (CT), Fas-associated protein 1, hFAF1, HFAF1s, TNFRSF6, TNFRSF6 associated factor 1 antibody, FAF1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-FAF1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||FAF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potentiates but cannot initiate FAS-induced apoptosis.|
|Tissue Location||Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
FAF1 (Fas-associated protein factor 1) specifically interacts with the cytoplasmic domain of wild type, but not mutated, Fas in both yeast and mammalian cells. When transiently expressed in T cells, FAF1 potentiates Fas-induced apoptosis. In contrast to TRADD, FADD, and RIP, FAF1 lacks a DDH (Death domain homologous region) and cannot induce apoptosis independent of Fas activation.
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