|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||81538 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml), immunoprecipitation (20 µg/ml) and and Immunohistochemistry (5 µg/ml). However, the optimal concentrations should be determined individually.|
|Other Names||CD44 , homing cell adhesion molecule, cell adhesion molecule|
|Formulation||100 µg (0.2 mg/ml) protein A purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||HCAM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LHR, MDU2, MDU3, MIC4|
|Function||Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.|
|Tissue Location||Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells|
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Provided below are standard protocols that you may find useful for product applications.
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are tho µght to play an important role in embryogenesis and development. The CAM family includes NCAM (neuronal cell adhesion molecule), ICAM (intracellular adhesion molecule), PECAM (platelet/endothelial cell adhesion molecule), BLCAM (produced by alternative splicing of the CD22 gene), VCAM (vascular cell adhesion molecule), and HCAM (homing cell adhesion molecule, also designed CD44), etc.
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