|Reactivity||Human, Mouse, Rat|
|Calculated MW||42763 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~42 kDa of CCR2 in samples from human, mouse and rat origins. Reactivity to other species has not been determined.|
|Other Names||CCR2A, CCR2B, Chemokine CC Motif Receptor 2, CKR2, Monocyte Chemotactic Protein 1 Receptor,|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-CCR2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CCR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the CCL2, CCL7 and CCL12 chemokines. Transduces a signal by increasing intracellular calcium ion levels (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in lung, spleen, kidney, thymus and macrophages|
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Provided below are standard protocols that you may find useful for product applications.
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
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