|Application ||WB, IHC|
|Calculated MW||41955 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 36 kDa CXCR5 of human origin. Reactivity to other species has not been tested.|
|Other Names||CXCR5 , MDR15 , CD185 , C-X-C chemokine receptor type 5 , BLR1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CXCR5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expression in mature B-cells and Burkitt lymphoma cells|
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Provided below are standard protocols that you may find useful for product applications.
Chemokines play an important role in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. CXCR5 is one of the CXCR receptors, which is expressed in a variety of cells.
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