|Reactivity||Human, Rat, Bovine|
|Calculated MW||173994 Da|
|Application & Usage||Western blotting (1:200-1000). However, the optimal concentrations should be determined individually. The antibody recognizes both alpha (~170 kDa) and beta (~50 kDa) isoforms of Neurexin in samples from human, rat, and bovine origins. Reactivity to other species has not been tested.|
|Formulation||100 µl (1 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Neurexin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted. Note=Some isoforms seems to be secreted|
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Provided below are standard protocols that you may find useful for product applications.
Neurexins comprise a family of neuronal cell surface proteins present primarily in the brain. Neurexins are tho µght to serve as signaling receptors and may play a role in axon guidance and synaptogenesis. The cytoplasmic tail of neurexin interacts with the synaptic vesicle protein synaptotagmin and binds to CASK, a protein with homology to the PSD95 family of synaptic junction proteins.
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