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TLR7 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NYK1.1 |
| Other Accession | AAZ99026 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Application & Usage | Western blotting (1:500-1000 dilution). However, the optimal conditions should be determined individually. Ramos cell lysate can be used as a positive control. |
|---|---|
| Other Names | TLR7 , Anti-TLR7 , PRO285 , UNQ248 |
| Target/Specificity | TLR7 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µl affinity purified rabbit anti-TLR7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | TLR7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NFkB and s µggests that these receptors are involved in mediating inflammatory responses. TLR6 and TLR7 induce NFkB signaling upon activation, s µggesting they play a role in immune reponse. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.
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