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PPAR-alpha Antibody

Rabbit Polyclonal Antibody

  • WB - PPAR-alpha Antibody ABV10430
    1) 80 μg Jurkat cell lysate;2) 40 μg Jurkat cell lysate;3) 100 μg Rat liver lysate;4) 100 μg Rat kidney lysate .Blocking/Dilution buffer: 5% NFDM (1 hr at RT) / TBST E-Selectin Polyclonal Antibody used at 1:1000 dilution - O/N at 4C.Goat Anti-Rabbit IgG peroxidase conjugated used at 1:10,000 dilution – 1 hr at RT Predicted band size: ~ 52 kDa. (Isoform 1), ~ 19 kDa (Isoform 2). Observed band size: ~ 52 kDa. ~20 kDa cleaved fragment.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07869
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52225 Da
Additional Information
Gene ID 5465
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~52 kDa PPARα in human sample. A ~28 kDa cleavage fragment can also be detected in samples of human, mouse, and rat origins.
Other Names PPARA , PPAR , OTTHUMP00000042872 , hPPAR , MGC2452 , OTTHUMP00000028713 , NR1C1 , PPAR-alpha , MGC2237
Target/Specificity PPARa
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPPAR-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NR1C1, PPAR
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Cellular Location Nucleus.
Tissue Location Skeletal muscle, liver, heart and kidney.
Research Areas
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PPAR (Peroxisome proliferator-activated receptor) is a member of the nuclear hormone receptor superfamily and functions as a transcriptional activator. PPARα is preferentially expressed in liver, skeletal muscle, heart and kidney. PPARα is involved in regulation of lipid homeostasis. Its ligands include fatty acids, NSAIDs, prostaglandins, leukotriene B4, etc. PPARα transcriptionally regulates a variety of genes for enzymes and proteins involved in fatty acid metabolism and oxidation.

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$ 285.00
Cat# ABV10430
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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