|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Chicken|
|Calculated MW||36791 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml), immunoprecipitation, and Immunohistochemistry. However, the optimal conditions should be determined individually. The antibody detects proform (43 kDa) and the mature form (29 kDa) of cathepsin K.|
|Other Names||CTSK , CTSO2 , CTSO , CTSO1, PKND, CTS02 , PYCD , MGC23107 , EC 188.8.131.52|
|Formulation||100 µg (0.5 mg/ml) protein A purified rabbit anti-cathepsin K polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Cathepsin K Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Cathepsin G belongs to the serine protease class. Cathepsins are involved in various cellular events such as peptide biosynthesis, protein degradation, and apoptosis. Cathepsin K expression is highest in bone, cartilage, and skeletal muscle.
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