|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Horse|
|Calculated MW||57883 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml), Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody should recognize aromatase in samples from human, mouse, rat, bovine, porcine, pig, sheep, rabbit, horse and chicken origins. A 55 kDa band can be detected, corresponding to the expected molecular weight of Aromatase. An additional 35 kDa band (believe to be the cleavage product of Aromatase) can also be detected in Jurkat cells.|
|Other Names||25147 , Cyp19a1, Aromatase , Cyp19 , p450arom , ARO1, ARO 1, CPV, CYP19A1 , MGC104309|
|Formulation||100 µg (0.2mg/ml) affinity purified rabbit anti-Aromatase polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Aromatase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARO1, CYAR, CYP19|
|Function||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|
|Cellular Location||Membrane; Peripheral membrane protein.|
|Tissue Location||Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads|
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Provided below are standard protocols that you may find useful for product applications.
Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, fertility, and carcinogenesis. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.
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