Syndecan-4 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, IP |
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Primary Accession | P31431 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21642 Da |
Gene ID | 6385 |
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Application & Usage | Western blotting (0.5-4 µg/ml), Immunoprecipitation (5-10 µg/ml) and and Immunohistochemistry (5 µg/ml) (Frozen and paraffin sections). However, the optimal conditions should be determined individually. Other applications have not been determined. |
Other Names | SDC4 , SYND4 |
Target/Specificity | Syndecan-4 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) Protein A purified rabbit anti-Syndecan-4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | Syndecan-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SDC4 (HGNC:10661) |
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Function | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). |
Cellular Location | [Isoform 1]: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form. |
Tissue Location | Detected in fibroblasts (at protein level) (PubMed:36213313, PubMed:1500433). Also expressed in epithelial cells (PubMed:1500433). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Syndecans are type I integral membrane proteoglycans that are involved in cell-extracellular matrix adhesion and growth factor binding. Syndecan-1 is an matrix receptor which binds to Collagens, Fibronectin and Thrombospondin. Syndecan-1 and Syndecan-3 interact with MK (midkine), a growth/differentiation factor involved in embryogenesis. Syndecan-2 is highly expressed at areas of high morphogenetic activity, such as epithelial-mesenchymal interfaces and the prechondrogenic and preosteogenic mesenchymal condensations. Syndecan-4 functions cooperatively with integrins in the processes of cell spreading and focal adhesion assembly.
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